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IGF-1 LR3 is a synthetic analogue of insulin-like growth factor-1 with an extended N-terminus and arginine substitution. Research investigations are examining its interactions with IGF-1 receptors and insulin-like growth factor binding proteins. Studies explore its biochemical properties in relation to cellular proliferation pathways, protein synthesis mechanisms, and growth factor signaling. This material is for research purposes only and is not intended for human use.
Long R3 IGF-1, or IGF-LR3, is a synthetic analog of insulin-like growth factor 1 (IGF-1) that has been modified for increased potency and a longer half-life. This 83-amino acid peptide is a key area of research in the fields of cellular growth, proliferation, and differentiation. Its unique structure, which includes an arginine substitution and a 13-amino acid N-terminal extension, allows it to bind to the IGF-1 receptor with high affinity while demonstrating significantly reduced binding to insulin-like growth factor-binding proteins (IGFBPs). This characteristic enhances its biological activity, making it a subject of interest for studying muscle growth and repair, as well as its potential therapeutic applications.
Research into IGF-LR3 is exploring its role in stimulating satellite cell activation, a critical step in muscle fiber growth and the formation of new muscle cells. Studies have also indicated its potential to increase protein synthesis and accelerate recovery times after exercise. Furthermore, IGF-LR3 is being investigated for its effects on metabolism, including its ability to facilitate fat burning by obstructing the movement of glucose into cells. These properties make IGF-LR3 a valuable tool for researchers studying muscle physiology, aging, and various metabolic conditions. This product is intended for research purposes only.
CAS: 946870-92-4
PubChem CID: N/A (complex peptide)
Molecular Formula: C400H625N111O115S9
Molecular Weight: 9117.5 g/mol
Amino Acid Sequence: 83 amino acids with Arg substitution at position 3 and 13 additional N-terminal amino acids
Physical Form: Lyophilized Powder
Purity: ≥99%
Storage: -20°C, protected from light and moisture
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